** Bremner, J Douglas, 2002. Structural changes in the brain in depression and relationship to symptom recurrence. CNS Spectrums 2002 Feb; 7 (2): 129-30, 135-9.
* Menchetti, Rucci, Bortolotti, Bombi, Socco, Kraemer, Berardi, 2013. Moderators of remission with interpersonal counseling or drug treatment in primary care patients with depression: randomized controlled trial. British Journal of Psychiatry: the Journal of Mental Science, 5;0 (0).
COUNSELING RESEARCH DATA
The latest research data to date shows that depressed and/or anxious clients receiving "talk therapy" displayed a statistically significant improvement over the untreated control group and over SSRI antidepressants alone. *
Additionally, brain research shows that if a person ignores debilitating anxiety or depression for an extended period, that complex structural changes can take place in many regions in the brain, leading to profound changes in brain chemistry and mood disregulation. **